Menetrye Disease: How to Identify and Cure a Disease?

Who could get sick?

The causes of pathology are unknown. She can develop at any age. It is only known that men are sick three times more often than women. Pathology is more common in people infected with Helicobacter pylori and cytomegalovirus. Children under the age of 10 get sick more easily. They may have spontaneous recovery. In adult patients, pathology develops more slowly, but it progresses constantly.

What symptoms do the disease have?

Menetrye disease has no special and unique symptoms. About 75% of sufferers complain of abdominal pain. In 40% of patients, nausea, vomiting, weight loss and swelling are reported. One in four develop anemia, 10% have diarrhea. 4% of patients complain of early saturation. Anaemia is led by repetitive bleeding, which usually goes undetected — these are latent minor hemorrhagies and bruises in the stomach. Nausea and pain usually appear at the same time, and at the height of pain sensations, vomiting occurs, which brings relief.

Is the disease dangerous?

Menetrye’s disease is treated as a precancerous condition. Against the background of this disease, the risk of stomach cancer is about 15%.

How to diagnose the disease?

Menetrye disease is diagnosed based on several groups of traits. Simply put, the doctor evaluates symptoms, performs a gastroscopy, and also takes a biopsy (a fragment of the mucosa) and sends the resulting material to the lab for research.

Diagnosis criteria:

  • uniform increase of the mucosa folds in the stomach body — determined by gastroscopy;
  • foveolar hyperplasia, and glandular atrophy with reduced number of parietal and main cells — conclusion after morphological study of bioptate;
  • hypoalbuminemia — decrease of albumin level in blood and resulting from this condition swelling.

Sometimes an X-ray with barium contrast is used for diagnosis. It allows you to reveal a cluster of thick sinuous folds. More information is given by a CT scan. The CT scan shows thickening of the gastric walls.

How is the disease treated?

A high protein diet, fluid restriction, diuretics, periodic droppers with albumin are prescribed for maintenance therapy. The most important are medications that reduce inflammation in the stomach, reducing atrophy. Rebamipid-based drugs (such as rebagitis) are used to repair the mucosa, which act on all 3 of its layers.

Additionally, medications for symptomatic therapy can be used, which help to remove pain and nausea. Surgical treatment is performed only if Menetrye’s disease progresses and does not respond to treatment with pills. Full or partial removal of the stomach is performed. The operation is resorted to in extreme cases. The cause usually becomes gastrointestinal bleeding or too low levels of protein in the blood.

Author:Sergey Vyalov, gastroenterologist, hepatologist, candidate of medical sciences

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