Description of the drug
“Lozap” (Lozap) is available in tablets covered with a shell, different dosage from 12.5 mn (№90) to 50 mg (№50, №30). Also included in this group is the medicinal product “Lozap plus”. From “Lozap” it differs in composition. Thus, in “Lozap” the active substance is only one — potassium lozartan, and in “Lozap plus” – two: potassium lozartan and hydrochlorothiazide. Mannitol, microcrystalline cellulose, sodium crosscarmellose, magnesium stearate, povidone, macrogol, dimethicone, hypromellose, talc, dye yellow. The
pharmacological action of
“Lozap”” is an antihypertensive agent that blocks receptors of subtype AT1 and exerts an obstruction of binding of angiotensin 2 and receptors AT1, The drug has no effect on the kinin system, does not contribute to the accumulation of bradykinin. Lozap is a prodrug. Its active metabolite (carboxylic acid), which is formed during the biotransformation process, has an antihypertensive effect. When administered orally within one hour, “Lozap” reaches its maximum level in blood plasma, its metabolite of maxmal concentration reaches within 3-4 hours. The drug is excreted within nine hours. In the first two hours, losartan is excreted, and its active metabolite – for 9 hours. As has been identified during scientific medical research, the hypotensive effect is faster achieved in the combination of losartan and hydrochlorthiazide. Therefore, the combined drug “Lozap plus” copes most effectively with the problem.
Single intake of “Lozap” has an antihypertensive effect for 6 hours, then gradually during the day the effect will decrease. Therefore, you need to use “Lozap” all the time. When regularly taking the medication in the second to fourth week, the patient will feel the full antihypertensive effect of the drug. Blood pressure will keep normal. It should be noted that blood pressure reduction is observed equally in male and female individuals. Race in the antihypertensive process, noted during research, did not show itself in achieving a positive result. “Lozap” acts the same on everyone.
Indications for use
Lozap are prescribed to patients suffering from arterial hypertension in combination therapy – patients with chronic heart failure and in case of intolerance or non-ephectivity therapy when using ACE inhibitors. This drug is recommended to prevent cardiovascular diseases, including stroke, and reduce mortality in people with high blood pressure and left ventricular hypertrophy. Diabetic nephropathy in patients with diabetes, accompanied by arterial hypertension, is also treated with “Lozap”.
Method of use and dose
In arterial hypertension “Lozap” is prescribed once a day at a dose of 50 mg. If the effect is not achieved, the dosage should be doubled: 100 mg once a day or 50 mg 2 times a day.
Treatment of chronic heart failure should start at 12.5 mg per day, once. During the week, the dosage is gradually increased first to 25 mg and then to 50 mg. At the same time it is necessary to monitor the condition of the patient, his tolerance of the drug.
Patients taking in a high dose of diuretics, the initial dose of the drug is prescribed 25 mg. Gradually, the dose can be increased. For the elderly and those with kidney failure, the dose of the drug is not adjusted. Reduction of dose is necessary for people with liver disruption.
“ Lozap” is taken once (or 2 times a day) without chewing the tablet and washing it with plenty of water. It is possible to take the medicine at any time regardless of food intake.
“Lozap” are not recommended to be prescribed in case of intolerance of one or more components of the drug, as well as during the period pregnancy. Contraindicated “Lozap” in childhood.
During the use of “Lozapa”, allergic reactions, skin redness, urticaria, anaphylactic shock, nasal bleeding, arrhythmias, $ angina, myocardial infarction, vasculitis, anemia, joint pain, headaches, hypotonia, vasculitis, liver dysfunction, myalgia, oral mucosa dryness, vomiting, constipation, flatulence, anxiety, anxiety, sleep disorders, fainting, migraine In rare cases likely, impaired taste and vision, reduced libido, impotence.
When excessive use of the drug, there may be a decrease in blood pressure, tachycardia, sometimes bradycardia. Therapy aimed at removing products of the drug from the body is recommended to eliminate these symptoms.
Interaction with other drugs
When taking “Lozapa”, “Rifampicina” or “Fluconazole”, the level in the blood plasma of the active metabolite can decline. When using the drug with potassium-saving diuretics, potassium products need to control the level of potassium. Reduces the hypotensive effect of “Lozap” such drugs as “Indomethacin” and other NSAIDs. There was no decrease in effect when taken simultaneously with digoxin, phenobarbital, warfarin, erythromycin and cimetidine.
Store the drug should be in a dry dark place at a temperature not exceeding 30°C.
It is not recommended to use the drug to people suffering from liver disease. If you need to use the drug, reduce the dose and monitor the patient’s condition.
The drug can cause drowsiness, diffuse and affect the driving of the car and complex mechanisms, so it is not recommended to prescribe it to people, occupations which are associated with increased attention.$
While taking the drug, the use of alcohol is strictly prohibited.